Abstract:
The phasing out of antibiotic growth promoters (AGPs) in poultry production has accelerated the search for natural feed additives that can sustain or enhance animal health and performance. Brewer’s yeast (Saccharomyces cerevisiae), a by-product of the beer industry, has gained increasing attention as a functional feed ingredient due to its rich nutritional composition and biologically active compounds such as β-glucans, mannan oligosaccharides (MOS), and nucleotides. This review provides a comprehensive overview of the nutritional and functional properties of brewer’s yeast, with a particular focus on its autolysate form and its application in antibiotic-free poultry diets. Key aspects discussed include its chemical composition, digestibility, immune-modulating effects, and potential to improve growth performance and gut health. Comparative analysis with AGPs highlights brewer’s yeast as a safe, sustainable, and effective alternative capable of enhancing poultry production outcomes without contributing to antimicrobial resistance. The review also identifies research gaps and proposes future directions for optimizing the use of yeast-derived products in modern poultry nutrition