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Effective light absorption spectra of endogenic porphyrins in soft biotissue

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dc.contributor.author SONTEA, V. P.
dc.contributor.author ABRAMOVICH, N. D.
dc.contributor.author BARUN, V. V.
dc.contributor.author DICK, S. K.
dc.contributor.author SERYAKOV, A.
dc.date.accessioned 2020-05-27T08:32:25Z
dc.date.available 2020-05-27T08:32:25Z
dc.date.issued 2015
dc.identifier.citation SONTEA, V. P., ABRAMOVICH, N. D., BARUN, V. V. et al. Effective light absorption spectra of endogenic porphyrins in soft biotissue. In: EHB. E-Health and Bioengineering Conference : proc. of the intern. conf.: Nov. 19-21, 2015, Iasi, 2015, pp. 1-4. ISBN 978-1-4673-7545-0. ISBN: 978-1-4673-7544-3. en_US
dc.identifier.isbn 978-1-4673-7545-0
dc.identifier.isbn 978-1-4673-7544-3
dc.identifier.uri https://doi.org/10.1109/EHB.2015.7391435
dc.identifier.uri http://repository.utm.md/handle/5014/8401
dc.description Access full text - https://doi.org/10.1109/EHB.2015.7391435 en_US
dc.description.abstract Light action spectra for main skin chromophores are simulated. Endogenic porphyrins (Pp IX, Cp III, and Up III) are selected as target chromophores. They can produce singlet oxygen (SO) under tissue irradiation, which acts as a natural photosensitizer. The SO is toxic for, e.g., cancer cells. This process is known to be widely used in photodynamic therapy (PDT). It is shown by way of examples that skin irradiation by red light, where the porphyrins have local maxima of light absorption, can improve the generation of SO as compared with the irradiation at a wavelength corresponding to the absolute maximum of light absorption. We obtained that the said improvement of SO generation can be about 5 to 10 times at specific depths inside tissue and 2 to 12 times integrally for the whole dermis thickness. The presented results can provide new opportunities for the selection of the irradiation wavelengths under application of traditional PDT methods. en_US
dc.language.iso en en_US
dc.publisher IEEE en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject absorption en_US
dc.subject radiation effects en_US
dc.subject dermis en_US
dc.subject biomedical optical imaging en_US
dc.subject blood en_US
dc.subject optical surface waves en_US
dc.subject waves en_US
dc.title Effective light absorption spectra of endogenic porphyrins in soft biotissue en_US
dc.type Article en_US


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