The agri-food sector in the Republic of Moldova is a strategic for the national economy. During the 2020-2021 years, a study was conducted on the factors influencing the development of enterprises in the agri-food sector in the Republic of Moldova. The study was conducted by interviewing 638 companies from agri-food sector from all administrative regions of Moldova. As a result of the study it was established: In the national profile we can mention that the group of Economic risks obtained an average evaluation 4.08 points; for the Northern Region - 4.06 points; for the Southern Region - 4.08 points; for the Central Region - 4.09 points. The group of Political risks in national profile obtained an average rating of 4.04 points. For the Northern Region, it obtained an average rating of 4.03 points; for the Southern Region - 4.04 points; for the Central Region - 4.04 points. The technical-technological risks in the national profile obtained an average rating of 4.1 points, the Northern Region - 4.08 points; Southern Region - 4.11 points; Central Region - 4.1 points. The group of Ecological risks in national profile obtained an average rating of 4.06 points; Northern Region - 4.08 points; Southern Region - 4.03 points; Central Region. The legislative-legal risks in national profile obtained an average evaluation 4.05 points; Northern Region - 4.06 points; Southern Region - 3.99 points; Central Region - 4.05 points. Informational risks obtained an average rating of 4.02 points; Northern Region - 4.05 points; Southern Region - 3.98 points; Central Region - 4.01 points. In the national profile, the group of Moral Risks obtained an average rating of 4.04 points; Northern Region - 4.05 points; For the Southern Region - 4.04 points; Central Region - 4.04 points.