Cannabis sativa L. – a promising indigenous natural source of endocannabinoids for strengthening human health

Abstract

This article provides a bibliographic synthesis regarding the importance of endocannabinoids from the Cannabis sativa L. species. Forms of the Cannabis sativa L. species are found in the wild flora of the Republic of Moldova and are of significant interest due to their high endocannabinoid content. Cannabinoids represent the most extensively studied group of compounds, particularly because of their wide range of pharmacological effects on humans, including psychotropic activities. Most of the biological properties associated with cannabinoids are based on their interactions with the human endocannabinoid system. Endocannabinoids regulate or modulate a variety of physiological processes, including appetite, pain perception, mood, memory, inflammation, insulin sensitivity, and fat and energy metabolism. CBD (cannabidiol) exhibits anti-anxiety, anti-nausea, anti-arthritic, antipsychotic, anti-inflammatory, and immunomodulatory properties. In preclinical models of central nervous system diseases (such as epilepsy, neurodegenerative diseases, schizophrenia, multiple sclerosis), affective disorders, and central regulation of eating behavior, CBD has also demonstrated strong antifungal and antibacterial properties, including remarkably effective activity against methicillin-resistant Staphylococcus aureus (MRSA). Additionally, cannabidiol has anti- inflammatory and anticancer properties. We consider that Cannabis sativa L. is of significant interest for cultivation and utilization in the fortification of human health.