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Mode of Artemisinins’ Action on Oxidative Stress, Genomic and G-quadruplex DNA
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| dc.contributor.author | GINOSYAN, S. G. | |
| dc.contributor.author | CHILINGARYAN, G. V. | |
| dc.contributor.author | GRABSKI, H. V. | |
| dc.contributor.author | GHULIKYAN, L. A. | |
| dc.contributor.author | AYVAZYAN, N. M. | |
| dc.contributor.author | TIRATSUYAN, S. G. | |
| dc.date.accessioned | 2020-05-29T10:24:30Z | |
| dc.date.available | 2020-05-29T10:24:30Z | |
| dc.date.issued | 2019 | |
| dc.identifier.citation | GINOSYAN, G., CHILINGARYAN, G. V., GRABSKI, H. V. et al. Mode of Artemisinins’ Action on Oxidative Stress, Genomic and G-quadruplex DNA. In: ICNMBE: International conference on Nanotechnologies and Biomedical Engineering: proc. of the 4rd intern. conf., Sept. 18-21 : Program & Abstract Book , 2019. Chişinău, 2019, p. 135. ISBN 978-9975-72-392-3. | en_US |
| dc.identifier.isbn | 978-9975-72-392-3 | |
| dc.identifier.uri | https://doi.org/10.1007/978-3-030-31866-6_97 | |
| dc.identifier.uri | http://repository.utm.md/handle/5014/8455 | |
| dc.description | Access full text - https://doi.org/10.1007/978-3-030-31866-6_97 | en_US |
| dc.description.abstract | The present study was conducted to evaluate the effect of artemisinins’ on the level of lipid peroxidation (LPO), spontaneous chemiluminescence of the S-180 sarcoma homogenate and to study the nature of the interaction with canonical and non-canonical forms of DNA. Artemisinins are secondary metabolites of the medicinal plant Artemisia annua have anti-inflammatory, anticarcinogenic, immunomodulatory, antimicrobial, antihelminthic, antiviral, antioxidant and other properties. Our preliminary reverse virtual screening demonstrated that the ligand-binding domain of the human glucocorticoid receptor is the optimal target for artemisinin as well as for dexamethasone. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Tehnica UTM | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject | artemisinins | en_US |
| dc.subject | lipid peroxidation | en_US |
| dc.subject | chemiluminescence | en_US |
| dc.subject | sarcoma | en_US |
| dc.title | Mode of Artemisinins’ Action on Oxidative Stress, Genomic and G-quadruplex DNA | en_US |
| dc.type | Article | en_US |
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