Improvement of the Antibacterial Activity of Benzylpenicillin in combination with Green Silver Nanoparticles against Staphylococcus aureus

OHANYAN, S.; GRABSKI, H.; RSHTUNI, L.; TIRATSUYAN, S.; HOVHANNISYAN, A.

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dc.contributor.author	OHANYAN, S.
dc.contributor.author	GRABSKI, H.
dc.contributor.author	RSHTUNI, L.
dc.contributor.author	TIRATSUYAN, S.
dc.contributor.author	HOVHANNISYAN, A.
dc.date.accessioned	2020-05-23T07:32:17Z
dc.date.available	2020-05-23T07:32:17Z
dc.date.issued	2019
dc.identifier.citation	OHANYAN, S., GRABSKI, H., RSHTUNI, L. et al. Improvement of the Antibacterial Activity of Benzylpenicillin in combination with Green Silver Nanoparticles against Staphylococcus aureus. In: ICNMBE: International conference on Nanotechnologies and Biomedical Engineering: proc. of the 4rd intern. conf., Sept. 18-21 : Program & Abstract Book , 2019. Chişinău, 2019, p. 108. ISBN 978-9975-72-392-3.	en_US
dc.identifier.isbn	978-9975-72-392-3
dc.identifier.uri	https://doi.org/10.1007/978-3-030-31866-6_65
dc.identifier.uri	http://repository.utm.md/handle/5014/8333
dc.description	Access full text - https://doi.org/10.1007/978-3-030-31866-6_65	en_US
dc.description.abstract	The antibiotic resistance crisis is one of the most pressing public health issues worldwide. Nanoparticles (NPs) can offer a promising solution, since they have antibacterial properties, and can act as carriers for antibiotics and natural antimicrobial compounds. The purpose of this work was to study the antibacterial activity of silver nanoparticles, which are obtained by “green synthesis” from O. araratum extract, against S. aureus bacteria, as well as to study their combined action with antibiotic benzylpenicillin. The results show that the antibacterial effect of silver nanoparticles is higher than that of nanoparticles stabilized by the extract on the growth of S. aureus. It has been shown that benzylpenicillin can interact with the allosteric site of penicillin-binding protein 2a. It has also been shown that “green” AgNPs, which include phytocompounds of the extract of O. araratum can enhance the antibacterial effect of benzylpenicillin synergistically.	en_US
dc.language.iso	en	en_US
dc.publisher	Tehnica UTM	en_US
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 United States	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.subject	green silver nanoparticles	en_US
dc.subject	nanoparticles	en_US
dc.subject	Staphylococcus aureus	en_US
dc.subject	benzylpenicillin	en_US
dc.subject	antibacterial effects	en_US
dc.subject	penicillin-binding proteins	en_US
dc.subject	proteins	en_US
dc.title	Improvement of the Antibacterial Activity of Benzylpenicillin in combination with Green Silver Nanoparticles against Staphylococcus aureus	en_US
dc.type	Article	en_US