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Molecular trigger mechanisms for neurodegeneration process via mitophagy in Parkinson’s disease

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dc.contributor.author SOCHIRCA, Alexandra
dc.contributor.author SIDORENKO, Ludmila
dc.contributor.author SIDORENKO, Svetlana
dc.date.accessioned 2024-04-25T13:37:22Z
dc.date.available 2024-04-25T13:37:22Z
dc.date.issued 2024
dc.identifier.citation SOCHIRCA, Alexandra, SIDORENKO, Ludmila, SIDORENKO, Svetlana. Molecular trigger mechanisms for neurodegeneration process via mitophagy in Parkinson’s disease. In: Quo Vadis – Ethics of the Scientific Research: conf. NANO-2024, event devoted to the 60th anniversary of the Technical University of Moldova, 15-18 April 2024, Chişinău, Republica Moldova: Program and proceedings of the conference, Chişinău 2024, pp. 90-91. ISBN 978-9975-64-422-8. en_US
dc.identifier.isbn 978-9975-64-422-8
dc.identifier.uri http://repository.utm.md/handle/5014/26930
dc.description.abstract Parkinson’s disease (PD) is a chronically progressing neurodegenerative disorder, which is associated with the following clinical core features bradykinesia, tremor, and rigidity. It is considered the second most common central nervous system degenerative disorder, which occupies the second place after Alzheimer's disease. Its molecular mechanism lies in the process of mitophagy, which is involved in the development of a range of neurodegenerative diseases, and the mutation of PINK1 and Parkin genes. Goal: The evaluation of the molecular background of PD's pathogenesis. Conclusion: Thus, the main molecular mechanism for PD emergence is the accumulation of defective mitochondria, caused by the mutations of PINK1 and Parkin genes, the expression of which dysregulates the mitochondrial activity, leading to the accumulation of the defected mitochondria and disruption of the mitophagy. en_US
dc.language.iso en en_US
dc.publisher Technical University of Moldova en_US
dc.relation.ispartofseries NANO-2024 "Quo Vadis – Ethics of the Scientific Research", event devoted to the 60th anniversary of the Technical University of Moldova;15-18 April 2024, Chişinău, Republica Moldova
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject Parkinson’s disease en_US
dc.subject mitochondrial degradation en_US
dc.subject process of mitophagy en_US
dc.title Molecular trigger mechanisms for neurodegeneration process via mitophagy in Parkinson’s disease en_US
dc.type Article en_US


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