Artemisinin production using genetic and metabolomic engineering

Abstract

Currently, artemisinin extract from Artemisia remains the main source for medicine, and its concentration in this plant is 0.01–1.2% in dry weight, but its content is relatively higher in cultivated varieties. Artemisinin is the most effective agent used in the fight against malaria in the world, as well as its promising properties are reported to combat against several types of cancer, viral diseases like hepatitis, influenza, human immunodeficiency virus (HIV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19 (coronavirus disease 2019).