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Electrokinetic method for detection of DNA molecules

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dc.contributor.advisor DEV, Apurba
dc.contributor.author GALATONOVA, Tatiana
dc.contributor.author GEVARI, Moein Talebian
dc.contributor.author SAHU, Siddharth Sourabh
dc.date.accessioned 2023-09-15T10:28:08Z
dc.date.available 2023-09-15T10:28:08Z
dc.date.issued 2023
dc.identifier.citation GALATONOVA, Tatiana, GEVARI, Moein Talebian, SAHU, Siddharth Sourabh. Electrokinetic method for detection of DNA molecules. In: Conferinţa tehnico-ştiinţifică a studenţilor, masteranzilor şi doctoranzilor, Universitatea Tehnică a Moldovei, 5-7 aprilie 2023. Chișinău, 2023, vol. 2, pp. 140-144. ISBN 978-9975-45-956-3. ISBN 978-9975-45-957-7 (Vol.2). en_US
dc.identifier.isbn 978-9975-45-956-3
dc.identifier.isbn 978-9975-45-957-7
dc.identifier.uri http://repository.utm.md/handle/5014/24007
dc.description.abstract In this study, we demonstrate the possibility of the Si-glass microchip capturing DNA samples by functionalizing the surface with PNA molecules as the essential bioreceptive element. Measurements are carried out based on electrokinetic principles, where the measuring element is the streaming current appearing on the surface through the flow of the liquid in a capillary. The obtained measurements demonstrate an optimal concentration of 31.25μM PLL-Thiol that covers the active surface of the microchip to the maximum that allows the capture of samples used continuously without loss. Furthermore, the capture of DNA is observed by the multiple changes of the signal by ~5mV, which allows us, based on the results, to continue the research to obtain a biosensor suitable for detecting genetic mutations. en_US
dc.language.iso en en_US
dc.publisher Universitatea Tehnică a Moldovei en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject DNA molecules en_US
dc.subject zeta potential en_US
dc.subject streaming current en_US
dc.subject biosensors en_US
dc.subject surface functionalization en_US
dc.title Electrokinetic method for detection of DNA molecules en_US
dc.type Article en_US


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